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Combatting Anti-Vaccine Misinformation
1) How do I figure out what is true, and what is false, about vaccines?Open or CloseIt is a sad but undeniable fact that there is a lot of misinformation, and in some cases downright lies, circulating about vaccines. This is especially true for the MMR vaccine, but the pernicious effects of the “anti-vaxxers” movement have expanded to the HPV vaccine as well. A recent outbreak of measles in the US has affected more than 100 individuals in 21 states and the District of Columbia. This follows on the heels of outbreaks in 2017, 2016, 2015, etc., including a record number of 667 cases in 2014. How bad is this anti-vaccine mania? Wealthy neighborhoods in Santa Monica and Beverly Hills now have vaccination rates that are similar to those seen in Chad and South Sudan. At some schools more than 60 percent of the kids have filed “personal belief exemptions” that allow them to avoid vaccination.
Vaccine misinformation drains resources from public health departments and puts vulnerable people, especially children, at risk. Check out Steve Novella’s article The Harm of Anti-vaccine Misinformation: Anti-vaccine misinformation has a body count.
In my answers to the questions below I’ve listed a number of books and websites that I would recommend so you can learn the facts about how vaccines work, and why the anti-vaccine movement ignores the science.
In the case of HPV, the CDC has assembled a full page of educational and other resources. You can look at similar pages for other vaccines, including measles, shingles, polio, tetanus, and many others. The CDC also has developed an excellent full page graphic outlining all of the steps a vaccine must go through before it can be sold, as well as the systems in place to monitor the vaccine’s safety record after it enters the market. The Immunization Action Coalition produces all kinds of useful information for the public as well as healthcare workers.
Note: Some of the information on the internet, either in support of or against vaccines, is actually posted by Russian Trolls are spreading misinformation about vaccines on the internet. Their goal is simply to foment discord. Think critically about any vaccine information that you come across, either positive or negative.
You can also look at the website Media Bias/Fact Check, which maintains a list of conspiracy/pseudoscience websites that you do NOT want to be getting your information from, along with a list of science based websites that are factually based.
If you’re interested in the link between the anti-vaccine movement and conspiracy theories, take a look at this excellent video from Dr. David Robert Grimes, who studies these issues. A clear explanation as to what leads to vaccine hesitancy, and why it’s not worth the time to try to convince anti-vaccine conspiracy believers that they are wrong.
A good place to start is the History of Vaccine Safety page on the website of the Centers for Disease Control (CDC). You can also learn about the National Childhood Vaccine Injury Act of 1986 in this same place, and why it was necessary to develop this legislation.
A FREE newly published review paper in Feb. 2019 is an excellent source for getting a handle for what is, and what is not true, in vaccine safety.
DeStefano et al Principal Controversies in Vaccine Safety in the United States. Clinical Infectious Diseases, ciz135, https://doi.org/10.1093/cid/ciz135
If you want to learn about the various themes circulating in anti-vaccine rhetoric online, I recommend this excellent paper by Hoffman et al https://doi.org/10.1016/j.vaccine.2019.03.003 It’s not all about autism: The emerging landscape of anti-vaccination sentiment on Facebook. (FREE download).
Vaxopedia has a compilation of 100 myths about vaccines. Yes, there really are at least that many circulating.
The Skeptical Raptor blog has a pretty extensive collection of myths about the HPV vaccine, along with refutations to just about all of them.
The internet is full of misinformation regarding healthcare and biomedicine. A recent analysis showed that the Mayo Clinic’s website didn’t even crack the top 3,000 healthcare websites that are shared on social media.
Vaccination rates vary widely across the US. Check out this article and graphic to see where your state ranks in 2019.
Many of those who are opposed to vaccines will talk about issues of informed consent and their desire to see placebo controlled studies of vaccines. They don’t understand why such requirements are considered unethical by bioethicists. Check out Edward Nirenberg’s excellent discussion on this subject The Vaccine Study That Anti-Vaccine Activists Think They Want: It’s An Ethicist’s Nightmare and It Should Be Yours Too. Lots of good references here refuting vaccine myths.
Want to learn about the techniques anti-vaxxers employ to attack/debate people who don’t agree with them? It’s all explained on this page of Vaxopedia.
Want to see the types of vaccine injury stories anti-vaxxers will tell to convince you not to vaccinate your kid? These are used to induce FUD: fear, uncertainty, and doubt. It’s all explained on this page of Vaxopedia.
Want to know how vaccine injuries are diagnosed (and yes, there really are some)? Check out this page on Vaxopedia.
If you want to take a deep dive into why so many people believe false information about vaccines (and many other subjects), check out Denying to the Grave: Why We Ignore the Facts That Will Save Us by two psychology researchers, Sara and Jack Gorman. Published in 2016, it provides an in-depth look at why our brains developed this way, and steps that can be taken to combat this trend.
Check out this blog post which refutes 72 anti-vaxx arguments against vaccines. The Vaxplanations website has a lot of good info refuting numerous anti-vaxx tropes, with an especially clear explanation of the differences between injection and ingestion.
If you’re looking for a list of publications that have covered many of the topics that come up when discussing the overall safety and efficacy of the most common vaccines, check out this post on Medium which points out large numbers of published papers on the various topics.
You can also take a look at Assessing the State of Vaccine Confidence in the United States: Recommendations from the National Vaccine Advisory Committee
One of the topics that comes up frequently are the data stored in the VAERS (Vaccine Adverse Event Reporting System) database. The CDC has a very clear explanation about how this system works, and the limitations on the data within it. In short, info in the VAERS database does NOT represent cause and effect relationships. As the website says, “When evaluating data from VAERS, it is important to note that for any reported event, no cause-and-effect relationship has been established. Reports of all possible associations between vaccines and adverse events (possible side effects) are filed in VAERS. Therefore, VAERS collects data on any adverse event following vaccination, be it coincidental or truly caused by a vaccine. The report of an adverse event to VAERS is not documentation that a vaccine caused the event.” You can also take a look at the VAERS homepage, which again has a wealth of information including info on how to file an adverse event report.
Injuries caused by vaccines can be litigated in vaccine court, which is actually the Office of Special Masters of the US Court of Federal Claims. In vaccine court Special Masters are appointed by the Court to adjudicate vaccine claims. These are people who are considered experts in both vaccines and the law surrounding them. The vaccine court uses a no-fault system for litigating vaccine injury claims. The Special Master act as both judge and jury. Decisions reached by the Special Masters can be appealed. Vaccine court was set up as part of the National Vaccine Injury Compensation Program (NVICP). It was established by the 1986 National Childhood Vaccine Injury Act, which was signed into law in response to a threat to the nation’s vaccine supply. The NVICP is funded by an excise tax of $0.75 on each dose of vaccine. This fund is almost exclusively used to fund claims allowed by the vaccine court – these include compensation to cover medical and legal expenses, loss of future earning capacity, up to $250,000 for pain and suffering, and a death benefit of up to $250,000.
Vaccine court is only used for routine childhood vaccines – these include nearly 20 different vaccines. Adults and adult vaccines, with a few exceptions, are excluded from filing NVICP claims and must pursue their cases in Federal or state civil courts. To win an award in vaccine court, the petitioner must have experienced an injury from the vaccines, sometimes called a “table injury”, i.e. an injury that appears in an extensive table maintained by the NVCIP. Separately, for non-table injury claims, the plaintiff must show a causal connection between the vaccine and the injury. The burden of proof in these cases follow the civil law preponderance-of-the-evidence standard – that is, over 50% of the evidence supports the claim. This is a much lower standard than in regular court, where the standard is beyond-a-reasonable-doubt.
If you want to learn more about vaccine court, and how it differs from a regular court, read this article dispelling myths about the vaccine court. Many people don’t realize that:
1) vaccine court has a lower threshold of proof than a regular court does.
2) litigants legitimate expenses are covered by the court. This does not happen in a regular court setting.
3) even if a litigant loses in vaccine court, they can take the case to civil court, and if they lose there, they can appeal that decision all the way up to the US Supreme Court.
Someone has actually gone to the trouble of searching through the VAERS database looking at “deaths” supposedly caused by Gardasil from 2011 through 2016. You can read the details here. A quick look will show you why nearly every single one of these claims are completely bogus. The vast majority of them are anecdotal reports with no associated data.
If you’re concerned about stories that vaccines cause allergic or autoimmune diseases, have your fears eased by reading this article in the journal Pediatrics by Paul Offit and Charles Hackett explaining why vaccines do NOT cause these diseases.
Check out this well written story about Why the Government Pays Billions to People Who Claim Injury by Vaccines to get a better understanding of the Vaccine Injury Compensation Program, the National Childhood Vaccine Injury Act of 1986 (also known as the Vaccine Act), and the Vaccine Injury Table, which details the many different illnesses, disabilities, and injuries that are presumed to be caused by a vaccine if no other cause is found.
We hear many claims from anti-vaccine folk about how vaccines have injured their kids. But are these claims true? Do parents have actual medical evidence to back up these claims? The answer is often that they don’t. Check out the process through which anti-vaccine advocates find women whose babies have died unexpectedly and convince them vaccines are to blame in How anti-vaxxers target grieving moms and turn them into crusaders. The article illustrates, using the story of Evee Clobes, that at least some cases of sudden infant death that parents blamed on vaccines have been found to have other causes (in this case, co-sleeping).
If you want to read a good analysis of why the autism rate has not really gone up over the past 50 years or so, check out There Is No Autism Epidemic. The article explains how different conditions that used to have different labels are now lumped together as autism spectrum disorders.
Finally, you should know that payments made to people who allege harm from vaccines are rare. Check out this excellent article Vaccine Injury Claims Are Few and Far Between detailing why this is the case. The graphic below is from that article:
2) Are there any good books to read about why people who oppose vaccinations are seriously misinformed?Open or CloseIndeed there are. Take a look at:
The Panic Virus: The True Story Behind the Vaccine-Autism Controversy by Seth Mnookin (2011). A detailed expose about the Andrew Wakefield/vaccines cause autism scandal in Great Britain. This book won the National Association of Science Writers Science in Society Book Award, and was named one of The Wall Street Journal's Top 5 Health and Medicine books of the year.
On a more personal level, I’d also recommend Vaccines Did Not Cause Rachel’s Autism: My Journey as a Vaccine Scientist, Pediatrician, and Autism Dad (inspired by his daughter) by Dr. Peter Hotez. As the title indicates Dr. Hotez is a pediatrician, a highly respected vaccine researcher, and the parent of a daughter with severe autism who suffers from intellectual difficulties. He explains the science regarding why vaccines don’t cause autism, what is thought to cause autism, and how he works to combat the voices of anti-vaccination groups.
Do Vaccines Cause That?! A Guide for Evaluating Vaccine Safety Concerns by Martin G. Myers, MD, and Diego Pineda (2008). Does exactly what the title says it does.
There are also four other books I can recommend to learn more about the anti-vaccine movement. Both were written or co-authored by Dr. Paul Offit, a very well known vaccine expert who led a successful effort to develop a vaccine against rotavirus (which can cause fatal diarrhea). This vaccine is saving the lives of hundreds of children across the world every day.
Deadly Choices: How the Anti-Vaccine Movement Threatens Us All (2012) - I highly recommend this one. It covers similar territory to the Panic Virus, but Mnookin’s book is written by a journalist, Offit’s book is written by a physician-researcher who has lived and breathed this subject for years. He is largely responsible for the development of the rotavirus vaccine, which saves the lives of hundreds of children somewhere in the world every day.
Bad Advice: Or Why Celebrities, Politicians, and Activists Aren’t Your Best Source of Health Information (2018) or to put it another way, why the internet isn’t the best place to get your health care information. In this book Dr. Offit explains why you shouldn’t be getting your healthcare advice from Gwyneth Paltrow and her ilk. He also explains why he seldom gets in front of the public to argue with anti-vaxxers. The book is a fast read and basically covers two ideas. About half of the book explains why much of the information available from people with no training in medicine or science is at best mostly worthless and at worst sometimes dangerous. He also gives some very good advice for scientists who are planning on engaging with the press to challenge this bad information. Much of this advice is based on his (few) professional career missteps and is meant to guide you to best handle (and hopefully avoid) lawsuits, death threats, biased debate moderators, and ineffective arguments from those you engage with.
Vaccines and Your Child: Separating Fact from Fiction by Paul Offit and Charlotte A. Moser (2011). This book is focused on allaying parent’s fears about vaccines.
Autism's False Prophets: Bad Science, Risky Medicine, and the Search for a Cure by Paul Moffit (2008). This book is an expose of all that went wrong when autism in children was unfairly linked to the MMR vaccine by a British doctor who’s research has been debunked.
In putting together this website, I’ve tried to always include links to authoritative sources for the data I’m quoting. However, I suggest you always consult your doctor or medical provider for the best and most recent information. Science and medicine change constantly as new discoveries are made, and I can’t guarantee that everything on even my website is up to date.
3) I want to learn why people who oppose the HPV vaccine (and others) are wrong. What are the facts?Open or CloseI’d start with this article, which is freely available online:
Robert A. Bednarczyk Addressing HPV vaccine myths: practical information for healthcare providers. Human Vaccines and Immunotherapeutics. (2019) https://doi.org/10.1080/21645515.2019.1565267
You might want to take a look at Answering human papillomavirus vaccine concerns; a matter of science and time by David Hawkes, Candice E Lea, and Matthew J Berryman from Infectious Agents and Cancer 2013, 8:22 (free, open access).
You can also take a look at this article from Dr. Paul Offit in which he reviews alleged autoimmune harms caused by the HPV vaccine. There is no linkage between the two. As one report concluded, “Investigators found no statistically significant differences between the vaccinated and unvaccinated groups in the incidence of immune thrombocytopenia, autoimmune hemolytic anemia, systemic lupus erythematosus (SLE), rheumatoid arthritis, juvenile rheumatoid arthritis, type 1 diabetes, Hashimoto disease, Graves disease, multiple sclerosis, acute disseminated encephalomyelitis, Guillain-Barré Syndrome (GBS), neuromyelitis optica, optic neuritis, or uveitis.”
I also came across an interesting website that has answers to questions that are frequently asked about HPV and cancer, but with two completely different answers to each question. One set of answers is taken from a conservative website (Conservapedia HPV vaccine FAQ), and the second answer to each question is a set of reality based responses based on the science. An interesting look at just how differently this subject is viewed, and how little science based information is available on the Conservapedia site.
You can take a look at this review by Naturopathic Doctor Elias Kass Human Papilloma Virus, which covers many of the basic facts about the virus, the vaccine, and the myths surround HPV.
In addition to reading the books I listed above, there are a number of resources that you can turn to. One that I recommend is the Respectful Insolence website. The author of this website, Dr. David Gorski, invests a lot of time debunking studies that purport to show damage caused by vaccines, including the HPV vaccine. As of August 2018, he’s written 148 different blog posts exposing the problems with these anti-vaccine studies. Among these posts are ones specifically focused on HPV. Here’s just one example you can look at: A dumpster fire of a study about HPV vaccination and female fertility, courtesy of Gayle Delong
Some of you might enjoy comedians Penn and Teller’s humorous explanation for why all modern vaccines have great value. There’s also a good music video with an HPV-tinted version of the song More Than Words, originally made popular by Extreme. This version is from ZDogg, MD the online identity of internist Zubin Damania, MD. It’s medically accurate, as you would expect from a doctor. There’s also a humorous video HPV Barbie, which unfortunately gets the facts wrong. It might get people talking about HPV, but it’s a good example of why you need to keep in mind that everything you hear about vaccines online is not true. I don’t think Mattel is going to like it, especially since they cite incorrect facts about the HPV vaccine.
Commentator and comedian John Oliver also had some good insights to share about the value of vaccines in this video from Last Week Tonight.
And here’s an excellent video comparing the risks of vaccinating, or not vaccinating, your kids against measles.
Check out Maki Nero’s excellent, science-based cartoon graphic Vaccines Work. Here Are the Facts. The risks, the misinformation, and the science behind history’s greatest life saver.
I’ll also recommend reporter Anna Merlan’s story Everything I Learned While Getting Kicked out of America's Biggest Anti-Vaccine Conference, which she describes as a radicalization event for the anti-vaccine crowd.
4) So you’re saying that all vaccines are completely safe?Open or CloseActually, I’m not. Vaccines are truly one of mankind’s greatest inventions, and they have saved hundred of millions of lives over the past few centuries. Vaccines, like many things, are not, and likely will never be, completely safe for every individual that receives them. With billions of doses having been given, it’s not at all surprising that there will be rare but serious side effects (see the list here from the CDC). However, you’re more likely to be attacked by a shark or hit by lightning than to suffer one of these. Good scientists acknowledge this fact, and will point out the issues involved. An opinion piece in the NY Times suggested that some scientists have gone overboard in defending vaccines against the anti-vaxxer crowd, hesitating to acknowledge that some vaccines do indeed cause rare problems for some people who get them. Vaccine expert Dr. Paul Offit responded by pointing out that these infrequent vaccine injuries have not been hidden. They’ve been published, often and widely, though the quality of these reports varies greatly. Good scientists know that bad science does get published, but as it tends not to be replicable, most of it eventually falls by the wayside.
This graphic provides a good look at the multiple elements that work to ensure that vaccines are safe, and if there problems, they are detected:
5) Since the HPV vaccine prevents numerous cancers, why is it so hard to have people act on that info?Open or CloseIt’s a complicated issue, but I can refer you to the following articles that discuss this:
Read about the many issues in getting people to want to be vaccinated in
Assessing the State of Vaccine Confidence in the United States: Recommendations from the
National Vaccine Advisory Committee. Approved by the National Vaccine Advisory Committee on June 10, 2015
What makes some parents fall for anti-vaccine messaging: Public health officials may not be hitting on the right morals in their quest to get all children vaccinated.
Here's The One Thing Scientists Have Found Will Change Anti-Vaxxers Minds: Logic is futile.
The 'Attitude Roots' Underlying Antivaccination Beliefs
Inadvisable anti-vaccination sentiment: Human Papilloma Virus immunisation falsely under the microscope, Head ed all npj Vaccines volume 2, Article number: 6 (2017)
A Hundred Thousand Wombs by Riko Muranaka, a personal look at how rumors about the safety of HPV vaccine in Japan caused vaccination rates to plunge. The author won an award for exposing these rumors as false. The story is also covered in Why Japan’s HPV vaccine rates dropped from 70% to near zero, and how one doctor is fighting back.
6) Is there a good site on the internet to find out if rumors about vaccines are true or false?Open or CloseYes. The best site I’ve found on the internet for checking out ALL rumors (not just those about vaccines) is SNOPES.com. It’s very reliable, and you can read about the methodology that they use here.
Here’s an example of their debunking of a rumor about the HPV vaccine:
FALSE: Pediatricians’ Association Admits HPV Vaccine-Cancer Link: A misleading article claimed that an association of pediatricians had "admitted" a link between the human papillomavirus vaccine Gardasil and ovarian "failure" or cancer.
Another good choice is FactCheck.org, a Project of The Annenberg Public Policy Center.
7) Are there any good TED talk videos online about vaccines, vaccine safety, and fear of vaccines?Open or CloseThere are quite a few of these. The descriptions below are all taken directly from the online details about the TED talks on You Tube.
Seth Berkley: The troubling reason why vaccines are made too late, if they’re made at all. 7:17 in length (from 2015).
“It seems like we wait for a disastrous disease outbreak before we get serious about making a vaccine for it. Seth Berkley lays out the market realities and unbalanced risks behind why we aren't making vaccines for the world's biggest diseases.”
Tara Haelle: Why Parents Fear Vaccines. 12:15 in length (from 2016)
“Tara Haelle will focus on vaccine hesitancy and vaccine refusal. This is a global health threat that lurks unnoticed until it erupts into unpredictable disease outbreaks that are difficult to contain. She explains what underlies the fear and hesitancy that many people have toward vaccines, why it's not as irrational as some believe, and what's necessary to address it.”
Danielle Stringer: Why I Changed My Mind On Vaccinations. 16:28 in length (from 2017)
“”Vaccines are BAD! Wait! Vaccines are GOOD!" - Pediatric Nurse Practitioner, Danielle Stringer, shares her experience and ideas that caused her to leave her vaccine-hesitancy behind and advocate for immunizations.”
Dr. Lindsay Levkoff Diamond: Vaccination: A Story of Risk & Community. 13:09 in length (from 2015)
“Herd immunity works for vaccinations as it does Facebook share fact checking. Dr. Lindsay Diamond discusses the risk about the vaccination choice that parents face. What is risk and what does community do to our choices?”
Catharine Young: Tracking the journey of vaccines. 4:22 in length (from 2017)
“Why are so many vaccines manufactured never getting to the public to save lives? Neuroscientist and TED Fellow Catherine Young uncovers the answer through her mobile app that tracks the journey of vaccines by monitoring drivers. The data she gathers will help uncover weak points in the supply chain, and allow for specific solutions.”
8) What general talking points to you recommend when trying to convince people to vaccinate their kids?Open or CloseLet me point you to two really excellent resources:
The WHO has published Best Practice Guidance: How to Respond to Vocal Vaccine Deniers in Public. This is freely available online. Here’s what’s covered:
Chapter 1: Introduction
1.1. What situation does this document address?
1.2. The term vaccine denier
1.3. Who are vocal vaccine deniers?
Chapter 2: The target audience
2.1. Understanding the target audience
Chapter 3: The speaker
3.1. Who should be the spokesperson?
3.1.1. Being a good speaker
3.1.2. Being a good listener
3.2. Do’s and don’ts of communication
Chapter 4: The argument
4.1. Response to vocal vaccine denier
Chapter 5: Unfavorable interview conditions
Chapter 6: Embracing the opponent
Chapter 7: Religious beliefs
7.1. How to respond to religious concerns?
Chapter 8: How to behave in a passionate discussion
Chapter 9: Participating – or not
Chapter 10: Fake experts
Chapter 11: What now?
Annex 1: HURIER model of listening instruction
Here are a number of talking points, borrowed from vaccine expert Dr. Peter Hotez, from his book Vaccines Did Not Cause Rachel’s Autism: My Journey as a Vaccine Scientist, Pediatrician, and Autism Dad (inspired by his daughter):
1) Childhood vaccines save lives
2) Childhood vaccines do NOT cause autism, plain and simple
3) Autism is caused by something other than vaccines
4) There is an abundance of deliberately misleading information about vaccines on the Internet
Dr. Hotez has also highlighted a number of myths that circulate widely
1) Mandatory vaccination is part of some type of conspiracy
2) These infectious diseases are gone, and therefore we don’t need vaccines
3) More children die in the US from vaccines compared to the diseases they prevent
4) Our body’s own “natural immunity” provides adequate protection from these infectious diseases
5) There’s a need to be concerned about vaccine ingredients
9) Got any resources for doctors and other medical professionals regarding how to get patients to accept the HPV vaccine?Open or CloseI think there are actually a large number of these. I’ll add to this list over time. Let’s start with:
The CDC has this helpful one page guide for talking to parents about the HPV vaccine. They also have this general guide for talking to parents about all vaccines.
Here’s advice about talking to vaccine-hesitant parents from the American Academy of Pediatrics.
The World Health Organization also has a resource for talking to parents about vaccines.
Here’s advice from the Canadian Pediatric Society in dealing with vaccine hesitant parents.
And a guide from vaccineresources.org, a handbook for healthcare workers and parents from PATH
ACIP (Advisory Committee on Immunization Practices) guidelines can be found on this page of the CDC website.
Vaccination resources from the WA state Dept. of Health can be found here.
Here’s a good article looking at approaches that work, and those that don’t, in convincing parents to vaccinate their kids. Bottom line: don’t ask about vaccination; simply be presumptive and tell parents it’s time for vaccination. If parents have concerns, acknowledge them, answer any questions they have, and tell them that in your professional judgement the risks are minor with vaccines, and the benefits greatly outweigh them.
HPV IQ - Immunization improvement, assessment, and feedback tools, along with communication training tools.
The CDC’s AFIX program - AFIX is a quality improvement program conducted by CDC’s immunization program awardees to support Vaccines for Children (VFC) providers in their jurisdiction. The goal of the AFIX program is to increase vaccination of children and adolescents with all Advisory Committee on Immunization Practices (ACIP)-recommended vaccines by reducing missed opportunities to vaccinate and improving immunization delivery practices at the provider level. The AFIX program consists of four components: Assessment, Feedback, Incentives, and eXchange.
10) Some anti-vaccine individuals and websites say that my religion doesn’t permit the use of certain vaccines, including the HPV vaccine. Is that true?Open or CloseIt’s not true. The real answer is that ALL of the major religions of the world are OK with ALL of the currently available vaccines, including the HPV vaccine. However, in some religious groups, some people have not been getting vaccinated due to social norms, not due to any prohibition by their religion. To learn more, check out this very comprehensive review of the subject that covers a wide range of religious groups, including all of the worlds major religions:
Grabenstein, J. What the World’s religions teach, applied to vaccines and immune globulins. Vaccine 31 (2013) 2011–2023. FREE download.
More info about how leaders from all religious groups endorse vaccines, and why creating newer vaccines to replace existing (and effective) vaccines can be seen in Religious Objections to the Measles Vaccine? Get the Shots, Faith Leaders Say
Not surprisingly, a study has found that when personal vaccine exemptions are eliminated in a state, the number of claims of religious exemptions for vaccinations rises. States that only offered religious exemptions were four times more likely to have children claiming religious exemptions than states where personal belief exemptions were also an option. In five states — Mississippi, West Virginia, California, New York, and Maine — medical exemptions are the only type of exemption a parent can claim. Religious exemptions are not allowed in those states, nor are personal belief exemptions. In the remaining 45 states and the District of Columbia, religious exemptions are available, even though no major religion objects to vaccination. Fifteen states also offer what is called a personal or philosophical exemption, which allows parents to say vaccinating their child would run counter to their beliefs. in 2019 Washington state eliminated the personal exemptions for the MMR vaccine only.
11) What are the specific claims about harms caused by the HPV vaccine, and who has debunked them?Open or CloseDispelling the Major HPV Vaccine Safety Myths
There’s a lot of misinformation on the Internet surrounding the HPV vaccine. I debated even covering this subject here, fearing that even mentioning any possible side effects would somehow cause people to believe them without checking out the data. For those of you who “like to do your own research”, you can start by looking at the reference sources I site below. There are a large number of studies that have been done, so I will focus on both the largest studies, as well as studies that compiled the results of previous studies.
Let me say at the outset that vaccines are NOT 100% safe. Any scientist or healthcare provider who makes such a claim is unbelievable. Drugs are also not 100% safe, and the same is true for all types of surgery. Nor are automobile airbags, bicycle safety helmets, or the foods we consume daily. Despite this fact, we use these things all the time because we know that the benefits of doing so greatly exceed the risks. The same is true for vaccines. They help keep us healthy, save lives, and prevent a great deal of disease-caused misery.
Let’s focus on the various HPV vaccines that have been used since 2006. What this vaccine was designed to do was to prevent cancer and, in the case of the two later Gardasil and Gardasil 9 vaccines, also prevent genital warts.
The HPV vaccine does NOT cause premature ovarian failure i.e. sterility
The HPV vaccine does NOT cause postural orthostatic tachycardia syndrome
The HPV vaccine does NOT cause complex regional pain or other neurological syndromes
The HPV vaccine does NOT cause demyelinating syndrome
The HPV vaccine does NOT cause venous thromboembolism
We know this because all of these have been looked at in vaccine safety studies.
Phillips, A. et al. Safety of Human Papillomavirus Vaccines: An Updated Review. Drug Safety April 2018, Volume 41, Issue 4, 329–346. This is a very complete review, but unfortunately, it’s behind a paywall.
The researchers compiled all of the data in a number of HPV vaccine studies published to date, including several different versions of the vaccine. They analyzed all of it, and here’s what they had to say, “We identified 109 studies, including 15 population-based studies in over 2.5 million vaccinated individuals across six countries. All vaccines demonstrated an acceptable safety profile; injection-site reactions were slightly more common for 9vHPV vaccine (Gardasil 9) than for 4vHPV vaccine (Gardasil). There was no consistent evidence of an increased risk of any adverse events of special interest.”
In a separate study, Scandinavian researchers looked for evidence of HPV vaccine side effects in nearly one million girls age 10-17. About 300,000 girls had gotten the vaccine; the remainder served as controls. Potential vaccine side effects had to be noted within 180 days of receiving the immunization. Here are their conclusions, “This large cohort study found no evidence supporting associations between exposure to qHPV vaccine [the original Gardasil vaccine] and autoimmune, neurological, and venous thromboembolic adverse events. Although associations for three autoimmune events were initially observed, on further assessment these were weak and not temporally related to vaccine exposure. Furthermore, the findings need to be interpreted considering the multiple outcomes assessed.”
Now their analysis did find some weak signals suggesting a possible involvement of the vaccine in three autoimmune diseases: Raynaud’s disease; type 1 diabetes, and Behcet’s syndrome. As a result, they did a more in-depth analysis of the data for these specific illnesses, and here is their conclusion: “While the study expands on the current safety information of the qHPV vaccine [Gardasil] by systematically assessing a range of serious adverse outcomes, the results need to be interpreted cautiously considering the large number of statistical tests performed; as well as the chance of false positive findings, true associations may have been missed. Although significantly increased rate ratios were initially observed for three outcomes, further assessment showed no consistent evidence for a plausible association; firstly, these risk signals were relatively weak, as assessed by pre-specified criteria, and, secondly, no temporal relation between vaccine exposure and outcome was evident. Thus, this study identified no safety signals with respect to autoimmune, neurological, and venous thromboembolic events after the qHPV vaccine had been administered.”
Arnheim-Dahlstrom, L. et al. Autoimmune, neurological, and venous thromboembolic adverse events after immunisation of adolescent girls with quadrivalent human papillomavirus vaccine in Denmark and Sweden: cohort study. BMJ 2013;347:f5906 doi: 10.1136/bmj.f5906 (Published 9 October 2013). This is a FREE open access article.
The Canadians have also looked for serious adverse events associated with the HPV vaccine. Here are the results of their study, “Over the period 2006-2014 195,270 females received 528,913 doses of HPV vaccine. Of those receiving at least one dose, 192 reported one or more AEFI events (198 AEFI events), i.e., 37.4/100,000 doses administered (95% CI 32.5-43.0). None were consistent with venous thromboembolism (VTE). Of the women who received HPV vaccine 958 were hospitalized and 19,351 had an ED visit within 42 days of immunization. Four women who had an ED visit and hospitalization event were diagnosed with VTE. Three of these had other diagnoses known to be associated with VTE; the fourth woman had VTE among ED diagnoses but not among those for the hospitalization.”
Liu, X.C. et al. Adverse events following HPV vaccination, Alberta 2006–2014. Vaccine, 34, 15, 2016, Pages 1800-1805. This is a FREE open access article.
In the spirit of overkill, I’ll give you a few more examples.
Researchers from Kaiser Permanente in CA looked for potential autoimmune side effects of the HPV vaccine in nearly 190,000 girls. The authors concluded, “Overall, 1014 potential new-onset cases were electronically identified; 719 were eligible for case review; 31–40%were confirmed as new onset. Of these, no cluster of disease onset in relation to vaccination timing, dose sequence or age was found for any auto-immune condition.”
Chao, C. et al. Surveillance of autoimmune conditions following routine use of quadrivalent human papillomavirus vaccine. J. Internal Med. 271, #2, 193-203 (2012). This is a FREE open access article.
The American Autonomic Society reviewed the literature containing the biology of the virus, pathophysiology of infection, epidemiology of associated cancers, indications of HPV vaccination, safety surveillance data and published reports linking HPV vaccination to autonomic disorders. They found “that there are no data to support a causal relationship between HPV vaccination and CRPS, chronic fatigue, and postural tachycardia syndrome to other forms of dysautonomia.”
Barboi, A. et al Human papillomavirus (HPV) vaccine and autonomic disorders: a position statement from the American Autonomic Society. Clin Auton Res (2019). https://doi.org/10.1007/s10286-019-00608-w
Researchers from Kaiser Permanente and the CDC looked at whether or not the HPV vaccine was associated with early menopause or primary ovarian insufficiency (POI). They found that there was NO association.Here are their findings:
“From a cohort of 199 078 female patients, we identified 120 with diagnoses suggestive of POI. After adjudication and exclusion of 26 POI cases with known causes, we confirmed 46 idiopathic POI cases. POI incidence was low in 11- to 14-year-olds (0.87 per 1 000 000 person-months) and increased with age. One confirmed case patient received the HPV vaccine 23 months before the first clinical evaluation for delayed menarche. CONCLUSIONS: We did not find a statistically significant elevated risk of POI after HPV, Tdap, II, or MenACWY vaccination in this population-based retrospective cohort study. These findings should lessen concern about POI risk after adolescent vaccination.”
Naleway, A.L. et al Primary Ovarian Insufficiency and Adolescent Vaccination, Pediatrics 142, 3 (2018).
The CDC has come to the same conclusion: “Before HPV vaccines were licensed, their safety was extensively studied in clinical trials. These studies found no difference in amenorrhea (when a woman of reproductive age doesn’t have a period) between women who got Gardasil compared to women who received a placebo. POI did not occur among women in the Gardasil clinical trials.
As part of ongoing safety monitoring of HPV vaccines, CDC has reviewed reports of POI to the Vaccine Adverse Event Reporting System (VAERS) following both Gardasil 9 and Gardasil vaccination. CDC has also conducted additional safety research on HPV vaccine in the Vaccine Safety Datalink (VSD):
Between December 1, 2014 and Dec 31, 2017, when 29 million doses of Gardasil 9 had been distributed in the United States, VAERS received 3 reports of POI following Gardasil 9 vaccination. The 3 reports were determined to be hearsay reports, meaning there was not enough information to confirm a diagnosis of POI.
Between January 2009 and December 2015, more than 60 million doses of Gardasil were distributed for use in the United States. During this time period, VAERS received 17 reports of POI following Gardasil vaccination. Two of these reports had a physician diagnosis of POI; the remaining 15 reports were considered hearsay reports, meaning there was not enough information to confirm diagnosis. Read the published article.
FDA and CDC reviewed the confirmed POI reports, investigating whether or not there was a pattern that might indicate the vaccine was causing the problem. There were no patterns found, making it unlikely the vaccine was the cause.”
Canadian researchers looked at adverse events in 195,000 young women following the HPV vaccine. Their overall conclusion: rates of adverse events were low, and consistent with those seen in other studies.
Liu, X. Adverse events following HPV vaccination, Alberta 2006–2014. Vaccine 34 (2016) 1800–1805 http://dx.doi.org/10.1016/j.vaccine.2016.02.040 This is a FREE open access article.
French researchers looked at adverse events in females 11-25 at specialized centers and followed them for six years. They looked at the incidence of a number of autoimmune conditions including central demyelination/multiple sclerosis (CD/MS), connective tissue disease (CTD), Guillain-Barré syndrome (GBS), type-1 diabetes (T1D), autoimmune thyroiditis (AT), and idiopathic thrombocytopenic purpura (ITP). No increase was found in any of these autoimmune diseases.
Grimaldi-Bensouda, L. Risk of Autoimmune Diseases and Human Papilloma Virus (HPV) Vaccines: Six Years of Case-Referent Surveillance. Journal of Autoimmunity 79 (May 1, 2017): 84–90. https://doi.org/10.1016/j.jaut.2017.01.005.
A paper by well known vaccine opponent (and non-scientist) Gayle DeLong claiming that the HPV vaccine leads to female sterility has been thoroughly debunked as false. You can read that analysis here.
The HPV vaccine also does not lead to death in young women. For this, I’ll refer you back to the above articles, but also to this debunking piece on Snopes.com.
The current HPV vaccine, Gardasil 9, contains aluminum as an adjuvant. While some anti-vaccine supporters claim the aluminum is toxic, this is NOT the case.
The CDC has a very clear explanation of why the aluminum is NOT problematic: “The current vaccine against HPV, Gardasil 9, is not a weakened virus vaccine. It contains but a single protein made by the virus. That’s why an adjuvant is used to generate a stronger immune response. In the case of Gardasil 9, this adjuvant is an aluminum based compound. Aluminum based adjuvants are the most commonly used ones in vaccines. The CDC notes that “aluminum salts, such as aluminum hydroxide, aluminum phosphate, and aluminum potassium sulfate have been used safely in vaccines for more than 70 years. Aluminum salts were initially used in the 1930s, 1940s, and 1950s with diphtheria and tetanus vaccines after it was found they strengthened the body’s immune response to these vaccines.”
To learn even more about the levels of aluminum in vaccines vs. the levels found in breast milk and formula, and why aluminum amounts in vaccines are too small to be harmful, check out this detailed Q&A from the Vaccine Information Center at the Children’s Hospital of Philadelphia. You can also look at this “aluminum in vaccines debunking the myths” article from the Skeptical Raptor blog.
You can also look at this page on vaxplanations to see a good explanation about why aluminum in vaccines is not a safety risk, or at this page produced by the Immunization Advisory Centre of New Zealand.
So the data are indeed available. The HPV vaccine is pretty darn safe. Not perfect, because no vaccine (or for that matter any drug) is, but very safe.
12) How can I tell the difference between good and bad science papers?Open or CloseThese are not alway easy to distinguish if you’re not a trained scientist, but it is doable. Brooke Fotheringham, mom and photographer with a passion for science communication and public health has written a terrific guide Recognizing good and bad science in vaccine research for separating the reliable scientific wheat from the disposable chaff. One of the techniques that she uses to do this is the Smell Test that was developed by author John McManus:
S stands for Source. Who is providing the information?
M is for Motivation. Why are they telling me this?
E represents Evidence. What evidence is provided for generalizations?
L is for Logic. Do the facts logically compel the conclusions?
L is for Left out. What’s missing that might change our interpretation of the information?
13) Where is the money coming from that funds the anti-vaccine movement?Open or CloseWe can’t be sure where all of this funding has been coming from, but a few U.S. families appear to have provided a good chunk of it:
One is the Dwoskin family and their eponymous Dwoskin Family Foundation. It is headed by Albert and Claire Dwoskin of McLean, VA; their money was made in real estate. They generally fund left-of-center causes, but are also behind the National Vaccine Information Center (see below) as well as the Children’s Medical Safety Research Institute, which provided grant funding to a number of anti-vaccine advocates. In June 2019, Al Dwoskin announced that he was no longer supporting the Children’s Medical Safety Research Institute because “After seeing a great deal of evidence, I have concluded that concerns about the safety of vaccination are unfounded.” “The best way to protect children is to make sure they have all their vaccinations as recommended by scientists, doctors and other healthcare professionals.” “The CMSRI, founded by my estranged wife, has been closed. I regret my participation in the CMSRI’s work and disagree with her views on the dangers of vaccination.” “My foundation no longer supports work on this issue.”
Businessman Barry Segal and his wife Clara provide funding for Focus for Health, which, among its activities, emphasizes vaccine hesitancy, as you can see by the graphic here.
The other group providing funding are hedge fund manager Bernard Selz and his wife Lisa, who are major funders of the anti-vaccine organization The Informed Consent Action Network (ICAN) via their Selz Foundation. You can read details in this Wall Street Journal article from 2019. They have been financially supporting the anti-vaxx movement since 2012. Thanks largely to the Selzes’ donations, ICAN is now the best-funded among a trio of organizations that have amplified concerns about vaccines. ICAN brought in $1.4 million in revenue in 2017, with just over $1 million being supplied by the Selz Foundation, according to tax filings. What was that money spent on? According to the WSJ article, “Tax filings show the charity spent more than $600,000 that year on legal fees. In 2018, the organization filed Freedom of Information Act lawsuits against federal agencies, including the Food and Drug Administration, the National Institutes of Health and the Department of Health and Human Services. The suits sought to compel the release of data and documents related to vaccine safety. Another quarter of a million dollars went toward salaries for two ICAN officers: Catharine Layton, the group’s chief administrative officer, was paid $98,000. And Bigtree, who was previously unpaid by the charity, drew a salary of $146,000.”
According to this Wall Street Journal article, the Children’s Health Defense, a charity run by Robert F. Kennedy, Jr. that promotes an anti-vaccine agenda, brought in $727,000 in 2017, according to tax filings. Barbara Loe Fisher, who says her son was injured by vaccines, runs a Virginia-based nonprofit that combats legislative efforts to tighten vaccine requirements. Her group, the National Vaccine Information Center (NVIC), brings in about $1 million a year, according to its 2018 tax documents.
The National Vaccine Information Center is supported, in large part, by Dr. Joseph Mercola, and osteopath who runs a business promoting natural health products (but no longer sees patients). He’s given NVIC nearly $3 million over the past decade. The connection between Dr. Mercola and the NVIC was revealed in this Washington Post article, and ads for Dr. Mercola’s businesses appear on websites tied to the NVIC. He’s also made a YouTube video with Barbara Loe Fisher using vaccine skepticism around flu shots. Dr. Mercola says he has a net worth in excess of $100 million, much of it coming from sales of products that he claims can help to prevent disease. The FDA has sent him warning letters on several occasions that he was promoting products that he said would treat various diseases, which is expressly forbidden by the agency.
Who’s Running Anti-Vaccine Ads on Facebook?
A recent study looked at anti-vaccine ads run on the social media site. As reported by Arstechnica, just two organizations were responsible for the majority of anti-vaccine advertisements on Facebook before the Facebook restricted such content in March 2019. “Of 145 anti-vaccine Facebook advertisements that ran between May 31, 2017 and February 22, 2019, the World Mercury Project and a group called Stop Mandatory Vaccination together ran 54% of them. The World Mercury Project, which ran the most ads of any single source, is an organization closely aligned with the anti-vaccine group Children's Health Defense. Both are spearheaded by Robert F. Kennedy Jr., an environmental lawyer turned prolific peddler of dangerous anti-vaccine misinformation. He and his organizations promote conspiracy theories about vaccine safety, including the roundly debunked claim that safe, life-saving immunizations are linked to autism. More recently, Kennedy has become a prominent opponent of laws aimed at increasing vaccination rates among school children.
Stop Mandatory Vaccination is a for-profit venture run by a man named Larry Cook. He, too, trumpets vaccine misinformation and fear-mongers. On Facebook and other platforms, Cook runs advertisements and campaigns making dubious links between the vaccines and tragic baby deaths. One such ad was banned by the UK's Advertising Standards Authority last year. The regulator determined the ad to be "misleading," "unsubstantiated," and "likely to cause undue distress." In other instances, he has claimed that the pro-vaccine medical community is covering up the "slaughter" of children.”